Scholarlink

<p>Proton boron capture therapy (PBCT), based on proton-boron fusion reactions (<sup>11</sup>B + p →3α + 8.7&#xa0;MeV), has the potential to enhance the biological effectiveness of proton therapy. To achieve this potential, the efficient delivery of enough <sup>11</sup>B to cancer cells will be paramount. This study demonstrates a newly developed method of poor solvent–mediated spontaneous assembly of polymeric micelles with entrapped <i>o</i>-carborane, in which ethanol is a good solvent for the payload <i>o</i>-carborane but a poor solvent for the hydrophobic segment poly(ε-caprolactone) in this amphiphilic block copolymer. This method provided smaller polymeric micelles compared to use of tetrahydrofuran, a good solvent for the amphiphilic block copolymer, as the sole solvent for both payload and copolymer. The prepared nanoscale formulation enabled the boron-rich cage compound <i>o</i>-carborane to be effectively delivered to tumor cells, and its enhancement of the biological effectiveness of proton therapy was preliminarily validated in a pancreatic ductal adenocarcinoma cell line, MiaPaCa-2, by survival assays and DNA damage assessment. The <sup>111</sup>In-labeled congener was also successfully prepared and used in biodistribution assays in normal mice, opening the way to further studies on image-guided PBCT in preclinical animal models.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

o-carborane encapsulated into polymeric micelles for proton boron capture therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月28日

查看全文
  • Guodong Zhang,
  • Qiu-Xu Teng,
  • Célia Fernandes,
  • Haiyan Chen,
  • Filipa Mendes,
  • Narayan Sahoo,
  • Ping Pan,
  • Lurdes Gano,
  • António Paulo,
  • Chun Li

摘要

Proton boron capture therapy (PBCT), based on proton-boron fusion reactions (11B + p →3α + 8.7 MeV), has the potential to enhance the biological effectiveness of proton therapy. To achieve this potential, the efficient delivery of enough 11B to cancer cells will be paramount. This study demonstrates a newly developed method of poor solvent–mediated spontaneous assembly of polymeric micelles with entrapped o-carborane, in which ethanol is a good solvent for the payload o-carborane but a poor solvent for the hydrophobic segment poly(ε-caprolactone) in this amphiphilic block copolymer. This method provided smaller polymeric micelles compared to use of tetrahydrofuran, a good solvent for the amphiphilic block copolymer, as the sole solvent for both payload and copolymer. The prepared nanoscale formulation enabled the boron-rich cage compound o-carborane to be effectively delivered to tumor cells, and its enhancement of the biological effectiveness of proton therapy was preliminarily validated in a pancreatic ductal adenocarcinoma cell line, MiaPaCa-2, by survival assays and DNA damage assessment. The 111In-labeled congener was also successfully prepared and used in biodistribution assays in normal mice, opening the way to further studies on image-guided PBCT in preclinical animal models.