Scholarlink

Purpose <p>To report a series of patients with acute-onset endophthalmitis caused by culture-proven <i>Staphylococcus lugdunensis</i> and to provide an update on the microbiologic susceptibility and clinical outcomes resulting from this organism.</p> Observations <p>This study included 6 eyes of 6 patients. The etiologies included cataract surgery (4), intravitreal injection (1), and posterior segment surgery (1). All isolates (100%) of <i>S. lugdunensis</i> demonstrated sensitivity to vancomycin with minimal inhibitory concentration (MIC) values ranging from ≤ 0.5 to 1 mcg/mL and to moxifloxacin with MIC values ranging from ≤ 0.25 to 1 mcg/mL. One of 6 isolates demonstrated intermediate resistance to gentamicin with a MIC value of 8 mcg/mL. Four of 6 patients underwent pars plana vitrectomy following initial treatment with intravitreal antibiotics, and 1 eye underwent vitrectomy as initial management. Best-corrected visual acuity at last follow-up examination was<i>≥</i> 20/150 in 5/6 (83.3%) of cases and <i>≥</i> 20/40 in 3/6 (50%) of cases.</p> Conclusion and importance <p>In this study, patients with acute-onset endophthalmitis caused by <i>S. lugdunensis</i> had relatively good outcomes, similar to a previous case series. Vancomycin continues to have consistent coverage against <i>S. lugdunensis</i> and remains an empiric therapeutic option for acute-onset endophthalmitis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical features and treatment outcomes of acute-onset endophthalmitis caused by Staphylococcus lugdunensis: a case series

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月7日

查看全文
  • Justin A. Chen,
  • Michael Y. Zhao,
  • Lauren C. Kiryakoza,
  • Salomon Merikansky,
  • Landon J. Rohowetz,
  • Darlene Miller,
  • Harry W. Flynn Jr.

摘要

Purpose

To report a series of patients with acute-onset endophthalmitis caused by culture-proven Staphylococcus lugdunensis and to provide an update on the microbiologic susceptibility and clinical outcomes resulting from this organism.

Observations

This study included 6 eyes of 6 patients. The etiologies included cataract surgery (4), intravitreal injection (1), and posterior segment surgery (1). All isolates (100%) of S. lugdunensis demonstrated sensitivity to vancomycin with minimal inhibitory concentration (MIC) values ranging from ≤ 0.5 to 1 mcg/mL and to moxifloxacin with MIC values ranging from ≤ 0.25 to 1 mcg/mL. One of 6 isolates demonstrated intermediate resistance to gentamicin with a MIC value of 8 mcg/mL. Four of 6 patients underwent pars plana vitrectomy following initial treatment with intravitreal antibiotics, and 1 eye underwent vitrectomy as initial management. Best-corrected visual acuity at last follow-up examination was≥ 20/150 in 5/6 (83.3%) of cases and ≥ 20/40 in 3/6 (50%) of cases.

Conclusion and importance

In this study, patients with acute-onset endophthalmitis caused by S. lugdunensis had relatively good outcomes, similar to a previous case series. Vancomycin continues to have consistent coverage against S. lugdunensis and remains an empiric therapeutic option for acute-onset endophthalmitis.