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Purpose <p>To assess retinal nerve fiber layer thickness by optical coherence tomography (OCT-RNFLT) in children with pars planitis and to examine its associations with visual acuity, binocular indirect ophthalmoscopy score (BIO), ocular signs and medical therapies.</p> Methods <p>This was a retrospective study. Demographic, clinical and imaging data were collected.</p> Results <p>Included were 29 children (50 eyes) with a mean age of 7.9 ± 2.9&#xa0;years. Presenting OCT-RNFLT (28 eyes) was 209.6 ± 179&#xa0;μm. Twenty-two eyes (78.6%) had OCT-RNFLT ≥ 130&#xa0;μm and it was significantly associated with higher BIO score (2.02 ± 1.21 vs. 0.42 ± 0.80 in eyes with OCT-RNFLT &lt; 130&#xa0;μm), anterior uveitis, papillitis, conventional disease-modifying antirheumatic drugs and biologic therapy. Following the initiation of therapy, improvement in BIO score was observed promptly, preceding the improvement in OCT-RNFLT. In the univariate general linear model, BIO group classification demonstrated the strongest association with RNFLT (<i>F</i> = 16.69, <i>p</i> &lt; 0.001). Papillitis was also significantly associated with higher RNFL values (<i>F</i> = 6.47, <i>p</i> = 0.015). Anterior uveitis did not show a significant association with RNFLT (<i>F</i> = 0.02, <i>p</i> = 0.883), suggesting that posterior segment findings could be more relevant indicators of RNFLT in this cohort.</p> Conclusion <p>To date, this is the first longitudinal study that investigated OCT-RNFLT in pediatric pars planitis patients. OCT-RNFLT strongly correlated with disease severity and eyes with OCT-RNFLT <i>≥</i>130&#xa0;µm required at a higher rate the institution of intensive immunosuppressive regimen. The reduction in OCT-RNFLT with resolving inflammation highlights its potential role as a tool for monitoring therapeutic response over time.</p>

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Implications of peripapillary retinal nerve fiber layer thickening by optical coherence tomography in children with pars planitis

  • 期刊论文

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  • 发表日期：

    2025年12月10日

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  • Diala Abu Al-Halawa,
  • Radgonde Amer

摘要

Purpose

To assess retinal nerve fiber layer thickness by optical coherence tomography (OCT-RNFLT) in children with pars planitis and to examine its associations with visual acuity, binocular indirect ophthalmoscopy score (BIO), ocular signs and medical therapies.

Methods

This was a retrospective study. Demographic, clinical and imaging data were collected.

Results

Included were 29 children (50 eyes) with a mean age of 7.9 ± 2.9 years. Presenting OCT-RNFLT (28 eyes) was 209.6 ± 179 μm. Twenty-two eyes (78.6%) had OCT-RNFLT ≥ 130 μm and it was significantly associated with higher BIO score (2.02 ± 1.21 vs. 0.42 ± 0.80 in eyes with OCT-RNFLT < 130 μm), anterior uveitis, papillitis, conventional disease-modifying antirheumatic drugs and biologic therapy. Following the initiation of therapy, improvement in BIO score was observed promptly, preceding the improvement in OCT-RNFLT. In the univariate general linear model, BIO group classification demonstrated the strongest association with RNFLT (F = 16.69, p < 0.001). Papillitis was also significantly associated with higher RNFL values (F = 6.47, p = 0.015). Anterior uveitis did not show a significant association with RNFLT (F = 0.02, p = 0.883), suggesting that posterior segment findings could be more relevant indicators of RNFLT in this cohort.

Conclusion

To date, this is the first longitudinal study that investigated OCT-RNFLT in pediatric pars planitis patients. OCT-RNFLT strongly correlated with disease severity and eyes with OCT-RNFLT ≥130 µm required at a higher rate the institution of intensive immunosuppressive regimen. The reduction in OCT-RNFLT with resolving inflammation highlights its potential role as a tool for monitoring therapeutic response over time.