<p>Dementia, including Alzheimer’s disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic review evaluates pharmacological and non-pharmacological interventions for managing agitation in dementia. Nine clinical studies were analyzed, encompassing medications like brexpiprazole and non-pharmacological approaches such as music therapy and digital care programs. Pharmacological treatments showed mixed efficacy and safety profiles, with brexpiprazole demonstrating dose-dependent benefits and mirtazapine associating with higher mortality rates. Non-pharmacological interventions exhibited promising results in reducing agitation without adverse effects. The review underscores the importance of personalized care strategies tailored to individual patient needs and preferences to enhance treatment efficacy and quality of life, highlighting the shift toward holistic, individualized care.</p>