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Objective <p>Tricyclic antidepressants (TCAs) are used to treat depression, but if abused or misused, they can cause poisoning, which can be fatal. The main treatment for TCA poisoning is administering sodium bicarbonate.</p> Methods <p>We report a 16-year-old girl diagnosed with nortriptyline poisoning with a profound neurologic and cardiovascular manifestations, successfully treated using sodium bicarbonate, intralipid emulsion, and plasmapheresis.</p> Conclusions <p>Plasmapheresis can be a good treatment modality for patients with TCA poisoning who do not respond well to classic treatments.</p>

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Successful outcome following intralipid emulsion and plasmapheresis in a patient with profound neurologic and cardiovascular manifestations due to nortriptyline poisoning: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月27日

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  • Asma Ahmadinejad,
  • Amir Saeed,
  • Marzieh Davoodi

摘要

Objective

Tricyclic antidepressants (TCAs) are used to treat depression, but if abused or misused, they can cause poisoning, which can be fatal. The main treatment for TCA poisoning is administering sodium bicarbonate.

Methods

We report a 16-year-old girl diagnosed with nortriptyline poisoning with a profound neurologic and cardiovascular manifestations, successfully treated using sodium bicarbonate, intralipid emulsion, and plasmapheresis.

Conclusions

Plasmapheresis can be a good treatment modality for patients with TCA poisoning who do not respond well to classic treatments.