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<p>This study aims to synthesize <i>Simarouba glauca</i> seed-mediated silver nanoparticles (Sg-AgNPs) through an eco-friendly approach and to evaluate their antioxidant, anti-inflammatory, and anticancer efficacy against HepG2 hepatocellular carcinoma cells. To characterize biosynthesized Sg-AgNPs’ optical properties, functional groups, crystallinity, morphology, particle size, and elemental composition, UV–Visible spectroscopy, FT-IR, XRD, SEM, TEM, and EDX were used. Nanoparticles exhibiting a surface plasmon resonance peak at 430&#xa0;nm and TEM showing 15–60&#xa0;nm spherical particles. Studies showed considerable antioxidant, anti-inflammatory, and cytotoxic actions against HepG2 cells, with an IC₅₀ value of 42.7&#xa0;µg/mL. Sg-AgNPs limit cancer cell growth via oxidative stress and apoptosis. These results demonstrate <i>Simarouba glauca</i>-mediated AgNPs as a durable and physiologically beneficial nanoplatform for hepatocellular carcinoma therapy.</p>

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Green synthesis of Simarouba glauca seed-mediated silver nanoparticles: physicochemical characterization and cytotoxic mechanisms in HepG2 hepatocellular carcinoma cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月14日

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  • V. Mariya Angel Augasta,
  • Venkatesh Rajendran,
  • B. Kowsalya,
  • R. T. Narendhirakannan,
  • S. Kathiravan,
  • Shobana Sampath,
  • Mohammad Z. Ahmed,
  • M. Dhinakaran,
  • Jayasutha Jayram,
  • Ali Kudamba

摘要

This study aims to synthesize Simarouba glauca seed-mediated silver nanoparticles (Sg-AgNPs) through an eco-friendly approach and to evaluate their antioxidant, anti-inflammatory, and anticancer efficacy against HepG2 hepatocellular carcinoma cells. To characterize biosynthesized Sg-AgNPs’ optical properties, functional groups, crystallinity, morphology, particle size, and elemental composition, UV–Visible spectroscopy, FT-IR, XRD, SEM, TEM, and EDX were used. Nanoparticles exhibiting a surface plasmon resonance peak at 430 nm and TEM showing 15–60 nm spherical particles. Studies showed considerable antioxidant, anti-inflammatory, and cytotoxic actions against HepG2 cells, with an IC₅₀ value of 42.7 µg/mL. Sg-AgNPs limit cancer cell growth via oxidative stress and apoptosis. These results demonstrate Simarouba glauca-mediated AgNPs as a durable and physiologically beneficial nanoplatform for hepatocellular carcinoma therapy.