Scholarlink

<p>Oxidative stress and chronic inflammation are key factors in tumor progression. Existing antioxidant and anti-inflammatory treatment methods are limited due to their specificity, bioavailability and impact on non-target sites. Plant-derived extracellular vesicles (PDEVs), as an innovative category of natural nanocarriers, effectively integrate therapeutic and delivery capabilities. They provide direct antioxidant and anti-inflammatory benefits by transporting bioactive phytochemicals and influencing key pathways. In addition, its inherent lipid bilayer structure promotes the effective encapsulation of therapeutic agents. Compared with synthetic systems, it has significant advantages in terms of biocompatibility, low immunogenicity and oral administration potential. However, the clinical application of PDEVs is hindered by challenges such as standardized isolation, batch-to-batch variability, unclear in vivo pharmacokinetics, and scalability. This review provides a critical synthesis of the current knowledge on PDEV biology, mechanisms of action, and engineering strategies, while offering a realistic analysis of translational prospects.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Plant-derived extracellular vesicles as a promising therapeutic and drug delivery strategy for tumor oxidative stress and inflammation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月19日

查看全文
  • Mengjuan Tao,
  • Xiayi Fang,
  • Zicheng Liang,
  • Zhen Zhang,
  • Wenling Gong,
  • Xiaoning Tan,
  • Puhua Zeng

摘要

Oxidative stress and chronic inflammation are key factors in tumor progression. Existing antioxidant and anti-inflammatory treatment methods are limited due to their specificity, bioavailability and impact on non-target sites. Plant-derived extracellular vesicles (PDEVs), as an innovative category of natural nanocarriers, effectively integrate therapeutic and delivery capabilities. They provide direct antioxidant and anti-inflammatory benefits by transporting bioactive phytochemicals and influencing key pathways. In addition, its inherent lipid bilayer structure promotes the effective encapsulation of therapeutic agents. Compared with synthetic systems, it has significant advantages in terms of biocompatibility, low immunogenicity and oral administration potential. However, the clinical application of PDEVs is hindered by challenges such as standardized isolation, batch-to-batch variability, unclear in vivo pharmacokinetics, and scalability. This review provides a critical synthesis of the current knowledge on PDEV biology, mechanisms of action, and engineering strategies, while offering a realistic analysis of translational prospects.