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<p>Chitosan, a natural biological macromolecule, was employed to coat boswellic acids extract nanoparticles (CT/BA NPs) to enhance their gastroprotective potential. This study evaluated the therapeutic effects of CT/BA NPs compared to free boswellic acids (BA) in a murine model of ethanol-induced gastric ulcers. Histological analysis showed that CT/BA NPs preserved gastric gland integrity and minimized inflammatory infiltration, achieving a ~ 97% reduction in ulcer index compared to the ulcer group, whereas BA alone achieved ~ 80% protection. CT/BA NPs treatment markedly modulated key growth factors, with TGF-α and TGF-β1 increased by more than 100% relative to the ulcer group, while VEGF expression was suppressed by ~ 74%, indicating more controlled angiogenesis. In addition, CT/BA NPs significantly reduced RAS and ERK levels (by ~ 1.6- and 1.2-fold, respectively) and lowered TNF-α compared to BA, highlighting their role in regulating the RAS–ERK signaling pathway. The superior mucoadhesive properties of CT/BA NPs (76.4% vs. 15.8% for BA NPs) improved gastric mucosal retention, contributing to localized therapeutic effects. Collectively, these findings demonstrate that CT/BA NPs provide promising gastroprotection by promoting epithelial healing, modulating growth factors and signaling pathways, and mitigating ulcer severity.</p>

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Mucoadhesive chitosan-coated boswellic acids nanoparticles as promising gastroprotective nanoagents via modulation of the RAS/ERK signaling pathway

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月23日

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  • Reem T. Attia,
  • Asaad Babker,
  • Mohamed S. Nafie,
  • Fatma Aboelmagd Saleh,
  • Manar Ashraf Abdelwareth,
  • Esraa Mahmoud Loutfy,
  • Ayman Ali Mohammed Alameen,
  • Sherif Ashraf Fahmy

摘要

Chitosan, a natural biological macromolecule, was employed to coat boswellic acids extract nanoparticles (CT/BA NPs) to enhance their gastroprotective potential. This study evaluated the therapeutic effects of CT/BA NPs compared to free boswellic acids (BA) in a murine model of ethanol-induced gastric ulcers. Histological analysis showed that CT/BA NPs preserved gastric gland integrity and minimized inflammatory infiltration, achieving a ~ 97% reduction in ulcer index compared to the ulcer group, whereas BA alone achieved ~ 80% protection. CT/BA NPs treatment markedly modulated key growth factors, with TGF-α and TGF-β1 increased by more than 100% relative to the ulcer group, while VEGF expression was suppressed by ~ 74%, indicating more controlled angiogenesis. In addition, CT/BA NPs significantly reduced RAS and ERK levels (by ~ 1.6- and 1.2-fold, respectively) and lowered TNF-α compared to BA, highlighting their role in regulating the RAS–ERK signaling pathway. The superior mucoadhesive properties of CT/BA NPs (76.4% vs. 15.8% for BA NPs) improved gastric mucosal retention, contributing to localized therapeutic effects. Collectively, these findings demonstrate that CT/BA NPs provide promising gastroprotection by promoting epithelial healing, modulating growth factors and signaling pathways, and mitigating ulcer severity.