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<p>In recent years, new medications like proteasome inhibitors (PIs) have significantly improved cancer patients’ response rate and overall survival. Carfilzomib (CFZ), a second-generation proteasome inhibitor, has shown promising results in clinical trials for treating multiple myeloma patients. In the current study, a Fe–Co metal-organic framework (MOF) was developed as a drug delivery system for targeted therapy of cancer cells. CFZ-loaded Fe–Co MOFs were synthesized and characterized using DLS, VSM, SEM-EDS, and BET analyses. The in vivo effects of CFZ-loaded Fe–Co MOFs were compared with standard drugs using a male Wistar rat model. Based on the results, DLS revealed a polydisperse size distribution, while VSM showed strong magnetic properties with 20 emu/g saturation magnetization. SEM-EDS confirmed a well-defined crystalline structure with uniform elemental distribution, and BET analysis indicated a mesoporous structure with a surface area of 84.984&#xa0;m<sup>2</sup>/g. The MOFs demonstrated a high drug loading efficiency of 74.86% and a controlled release profile, with an initial burst followed by sustained release. When administered intravenously to rats, free CFZ at doses of 0.4&#xa0;mg/kg and 0.8&#xa0;mg/kg led to significant increases in serum liver enzymes, kidney function markers, and liver malondialdehyde content. Furthermore, high doses of CFZ-loaded Fe–Co MOFs caused significant histopathological changes in the rats. These findings provide a basis for further research on using Fe–Co MOFs as carriers of proteasome inhibitors like CFZ for targeted drug delivery.</p>

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Histopathological and biochemical profiling of Carfilzomib-loaded Fe–Co MOFs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月14日

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  • Mohammad Reza Hajinezhad,
  • Mahmood Barani,
  • Saman Sargazi

摘要

In recent years, new medications like proteasome inhibitors (PIs) have significantly improved cancer patients’ response rate and overall survival. Carfilzomib (CFZ), a second-generation proteasome inhibitor, has shown promising results in clinical trials for treating multiple myeloma patients. In the current study, a Fe–Co metal-organic framework (MOF) was developed as a drug delivery system for targeted therapy of cancer cells. CFZ-loaded Fe–Co MOFs were synthesized and characterized using DLS, VSM, SEM-EDS, and BET analyses. The in vivo effects of CFZ-loaded Fe–Co MOFs were compared with standard drugs using a male Wistar rat model. Based on the results, DLS revealed a polydisperse size distribution, while VSM showed strong magnetic properties with 20 emu/g saturation magnetization. SEM-EDS confirmed a well-defined crystalline structure with uniform elemental distribution, and BET analysis indicated a mesoporous structure with a surface area of 84.984 m2/g. The MOFs demonstrated a high drug loading efficiency of 74.86% and a controlled release profile, with an initial burst followed by sustained release. When administered intravenously to rats, free CFZ at doses of 0.4 mg/kg and 0.8 mg/kg led to significant increases in serum liver enzymes, kidney function markers, and liver malondialdehyde content. Furthermore, high doses of CFZ-loaded Fe–Co MOFs caused significant histopathological changes in the rats. These findings provide a basis for further research on using Fe–Co MOFs as carriers of proteasome inhibitors like CFZ for targeted drug delivery.