<p>In this study, we investigated the psychological and physiological effects of wood-integrated material combinations. Although previous studies have examined responses to individual wood materials, the impact of combination of wood with other materials on such responses remains underexplored. We fabricated 22 material models incorporating wood, fabric, tile, and paint in various combinations and manipulating factors, such as wood coverage, material diversity, and brightness levels. Forty-four participants evaluated these models, and their psychological (measured through semantic differential scales) and physiological responses (skin conductance and temperature) were recorded. Wood was perceived as the warmest material, with warmth perception increasing with wood coverage. Material combinations featuring high diversity were rated as appealing and trending. Bright models were perceived as the most appealing and soft, whereas medium to dark tones were found to be stimulating. Notably, although fabric was the most appealing single material, its appeal diminished when combined with wood. These findings suggest that when integrating wood into interior design, careful consideration of the accompanying materials is essential to optimize positive human responses. This study offers valuable insights for designers and architects aiming to enhance well-being through strategic material combinations in built environments.</p>