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Abstract <p>One promising application of nuclear-physics methods in medicine is boron neutron capture therapy (BNCT). A key aspect of the effectiveness of BNCT is the production of boron-containing materials with the required concentration and the ability to keep the drug within the tumor. This work presents the results of the initial stage of boron-10 nanoparticle synthesis, which includes the synthesis of submicron particles by milling boron-10 in a planetary ball mill. Solutions of boron-10 in isopropanol with submicron particle sizes of 150–600 nm are obtained. The optimal milling conditions are determined to ensure the required boron-10 concentration and minimize the presence of impurities.</p>

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Synthesis of Submicron Particles of the Boron-10 Isotope by Mechanical Milling in Planetary Ball Mills

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. A. Fronya,
  • K. O. Fomin,
  • K. S. Pervakov,
  • I. M. Tupitsyn,
  • E. I. Mavreshko,
  • D. S. Petrunya,
  • M. S. Grigoryeva,
  • E. V. Barmina,
  • I. N. Zavestovskaya

摘要

Abstract

One promising application of nuclear-physics methods in medicine is boron neutron capture therapy (BNCT). A key aspect of the effectiveness of BNCT is the production of boron-containing materials with the required concentration and the ability to keep the drug within the tumor. This work presents the results of the initial stage of boron-10 nanoparticle synthesis, which includes the synthesis of submicron particles by milling boron-10 in a planetary ball mill. Solutions of boron-10 in isopropanol with submicron particle sizes of 150–600 nm are obtained. The optimal milling conditions are determined to ensure the required boron-10 concentration and minimize the presence of impurities.