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Abstract <p>The physical and chemical properties (size, ξ potential) of aqueous solutions of chitosans with different molecular weights (6, 26, and 50–80 kDa) and different degrees of deacetylation are studied using the dynamic light scattering method. Liposomes from a mixture of phosphatidylcholine and phosphoethanolamine (S75) with different types of chitosans adsorbed on the surface are also characterized and their stability is studied. Conditions for the preparation of S75 liposomes coated with chitosan and having a positive ζ potential, in the absence of free (not bound to the liposome surface) chitosan in the aqueous medium are selected. S75 liposomes with a lipid concentration of 2 mg/mL coated with 6 kDa chitosan (0.05%) and containing carotenoid astaxanthin esters (0.01 and 0.05 mg/mL) are obtained and characterized. The stability of astaxanthin esters in the liposomes is studied. The most stable are S75 liposomes containing 0.01-mg/mL astaxanthin esters and coated with 0.05% 6 kDa chitosan.</p>

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Chitosan-Coated Liposomes Containing Astaxanthin Esters

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. O. Suverneva,
  • E. A. Kulikov,
  • S. N. Malakhov,
  • N. Y. Lotosh,
  • A. A. Selishcheva

摘要

Abstract

The physical and chemical properties (size, ξ potential) of aqueous solutions of chitosans with different molecular weights (6, 26, and 50–80 kDa) and different degrees of deacetylation are studied using the dynamic light scattering method. Liposomes from a mixture of phosphatidylcholine and phosphoethanolamine (S75) with different types of chitosans adsorbed on the surface are also characterized and their stability is studied. Conditions for the preparation of S75 liposomes coated with chitosan and having a positive ζ potential, in the absence of free (not bound to the liposome surface) chitosan in the aqueous medium are selected. S75 liposomes with a lipid concentration of 2 mg/mL coated with 6 kDa chitosan (0.05%) and containing carotenoid astaxanthin esters (0.01 and 0.05 mg/mL) are obtained and characterized. The stability of astaxanthin esters in the liposomes is studied. The most stable are S75 liposomes containing 0.01-mg/mL astaxanthin esters and coated with 0.05% 6 kDa chitosan.