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Abstract <p>A method for producing composite materials for cranioplasty based on polylactide and poly-ε-caprolactone, which contain chitosan threads as a reinforcing filler, is described. Chitosan threads are obtained via wet spinning by precipitating acetic acid solutions of chitosan in an alcohol-alkaline medium. The melting temperatures of polylactide and poly-ε-caprolactone are significantly lower than the degradation temperature of chitosan, which makes it possible to obtain composite materials using heat-treatment methods, e.g., calendering and pressing. The composite material based on polylactide has strength and elastic characteristics close to those of cancellous bone tissue, and the composite based on poly-ε-caprolactone has those of cortical bone. This allows us to recommend the obtained composite materials for preclinical and clinical studies as bone-tissue implants, in pediatric cranioplasty for the treatment of injuries and diseases of the skull bones.</p>

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Development of Resorbible Composites Based on Chitosan Fibers for Bone Grafting

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • N. A. Tagandurdyeva,
  • G. V. Vaganov,
  • I. P. Dobrovol’skaya,
  • E. N. Dresvyanina,
  • E. N. Popova,
  • V. Yu. Elokhovskiy,
  • V. E. Yudin,
  • T. Wang

摘要

Abstract

A method for producing composite materials for cranioplasty based on polylactide and poly-ε-caprolactone, which contain chitosan threads as a reinforcing filler, is described. Chitosan threads are obtained via wet spinning by precipitating acetic acid solutions of chitosan in an alcohol-alkaline medium. The melting temperatures of polylactide and poly-ε-caprolactone are significantly lower than the degradation temperature of chitosan, which makes it possible to obtain composite materials using heat-treatment methods, e.g., calendering and pressing. The composite material based on polylactide has strength and elastic characteristics close to those of cancellous bone tissue, and the composite based on poly-ε-caprolactone has those of cortical bone. This allows us to recommend the obtained composite materials for preclinical and clinical studies as bone-tissue implants, in pediatric cranioplasty for the treatment of injuries and diseases of the skull bones.