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<b>Abstract</b>— <p>The purpose of the review is to summarize data on the stability of direct intercellular interactions and the reliability of their marker that are circahoralian (ultradian) biological rhythms. Some facts are scattered in different sections of my recently published book, but as a problem, they are discussed in the new review for the first time. The data on the temperature compensation of rhythms and, consequently, cell synchronization through intercellular interactions are discussed. The Gelfand’s model and our experimental data on cell self-synchronization in a constant environment are considered. The facts about the preservation of such connections during the hibernation of ground squirrels and in different seasons of the year in the dears are presented. The biochemical mechanisms of direct intercellular interactions are analyzed. The reliability and adaptability of the fractal kinetics of cellular metabolism and its importance in cell biology are substantiated. The idea of homeodynamics, which complements the concept of homeostasis, is supported.</p>

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Constancy of the Direct Cell-to-Cell Communication. From Early Embryos to Senescence

  • 期刊论文

  • 发表日期：

    2026年5月21日

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  • V. Ya. Brodsky

摘要

Abstract—

The purpose of the review is to summarize data on the stability of direct intercellular interactions and the reliability of their marker that are circahoralian (ultradian) biological rhythms. Some facts are scattered in different sections of my recently published book, but as a problem, they are discussed in the new review for the first time. The data on the temperature compensation of rhythms and, consequently, cell synchronization through intercellular interactions are discussed. The Gelfand’s model and our experimental data on cell self-synchronization in a constant environment are considered. The facts about the preservation of such connections during the hibernation of ground squirrels and in different seasons of the year in the dears are presented. The biochemical mechanisms of direct intercellular interactions are analyzed. The reliability and adaptability of the fractal kinetics of cellular metabolism and its importance in cell biology are substantiated. The idea of homeodynamics, which complements the concept of homeostasis, is supported.