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<b>Abstract</b>— <p>The review examines published data on the importance of the natural biopolymer of the polysaccharide nature of chitosan in the adaptive reactions of the body. The structure of chitosan and its modified derivatives is characterized with special attention to the functional groups responsible for viscosity and interaction with other components. The numerous properties of chitosan in the physiological processes of the body are described, and its ability to act as a regulator of hemostasis during the development of such a pathological condition as hypocoagulation is described in detail. The participation of the biopolymer in the normalization of the rheological and hemostatic properties of blood is shown. The data summarized in the review on the role of chitosan in the hemostasis system make it possible to open up new prospects for its use in order to restore the normal functioning of the blood coagulation and anticoagulation systems during hypocoagulation.</p>

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The Role of Chitosan in the Adaptation Reactions of the Body in Normal and under Hypocoagulation Conditions

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • L. A. Lyapina,
  • M. E. Grigorieva,
  • T. Yu. Obergan

摘要

Abstract—

The review examines published data on the importance of the natural biopolymer of the polysaccharide nature of chitosan in the adaptive reactions of the body. The structure of chitosan and its modified derivatives is characterized with special attention to the functional groups responsible for viscosity and interaction with other components. The numerous properties of chitosan in the physiological processes of the body are described, and its ability to act as a regulator of hemostasis during the development of such a pathological condition as hypocoagulation is described in detail. The participation of the biopolymer in the normalization of the rheological and hemostatic properties of blood is shown. The data summarized in the review on the role of chitosan in the hemostasis system make it possible to open up new prospects for its use in order to restore the normal functioning of the blood coagulation and anticoagulation systems during hypocoagulation.