Abstract <p>The catabolism of amino acids (AAC) is vital for cellular proteostasis and stress adaptation in plants, yet its transcriptional regulation in potato (<i>Solanum tuberosum</i>) under drought remains poorly understood. This study aimed to illuminate the regulatory networks governing AAC in potato under water stress conditions. Using publicly available transcriptomic data from drought-tolerant and -susceptible potato clones, differential expression and co-expression network analyses were performed. The analysis identified two key differentially expressed AAC genes (DEAACs): Asparaginase (<i>StASN</i>) and Hydroxymethylglutaryl-CoA lyase (<i>StHMGL</i>), both upregulated in the tolerant clone. The co-expression network revealed that these genes are linked to key stress-responsive transcription factors, including an orthologue of <i>DREB2C</i>, and numerous protein kinases, predominantly Receptor-like Kinases (RLKs) involved in stomatal regulation and hormonal signaling. These findings establish a direct molecular network linking amino acid metabolism with key hormonal and stress-signaling pathways in potato. This integrated network provides novel insights into the mechanisms of drought tolerance and identifies potential gene targets for improving crop resilience.</p>