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Abstract <p>Porous composite materials have been developed with a matrix composed of a mixture of polyvinylpyrrolidone (PVP) and sodium alginate (ALG), in which ceramic particles of double (manganese- and strontium)-substituted tricalcium phosphate (TCP) are distributed. X-ray diffraction analysis (XRD) demonstrated that the main crystalline phase of the (manganese and strontium)-substituted TCP is whitlockite. In vitro studies revealed that all tested materials are not adhesive to cells and exhibit no cytotoxic or inhibitory effects on them. The porous composite materials characterized by a high rate of bioreabsorption of ceramic particles and a strong potential for antibacterial activity and osteoinductive properties due to ion diffusion and changes in the surface layer properties can be used in reconstructive surgery for the restoration of bone tissue function.</p>

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Composite Porous Materials Made of Polyvinylpyrrolidone and Sodium Alginate and Double (Manganese and Strontium)-Substituted Tricalcium Phosphate for Medicine

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • I. V. Fadeeva,
  • A. B. Mikhailova,
  • G. A. Davidova,
  • L. I. Akhmetov,
  • O. S. Antonova,
  • K. K. Churakova,
  • I. I. Selezneva

摘要

Abstract

Porous composite materials have been developed with a matrix composed of a mixture of polyvinylpyrrolidone (PVP) and sodium alginate (ALG), in which ceramic particles of double (manganese- and strontium)-substituted tricalcium phosphate (TCP) are distributed. X-ray diffraction analysis (XRD) demonstrated that the main crystalline phase of the (manganese and strontium)-substituted TCP is whitlockite. In vitro studies revealed that all tested materials are not adhesive to cells and exhibit no cytotoxic or inhibitory effects on them. The porous composite materials characterized by a high rate of bioreabsorption of ceramic particles and a strong potential for antibacterial activity and osteoinductive properties due to ion diffusion and changes in the surface layer properties can be used in reconstructive surgery for the restoration of bone tissue function.