Abstract <p>The phase composition of materials obtained by heat treatment of titanium–copper powder mixtures with an elemental composition corresponding to the TiCu and Ti₂Cu binary intermetallic compounds has been studied. The heat treatment included short-term heating of mechanically activated mixtures to 800°C or sintering of compacts from the mixtures. It has been established that, regardless of a heat treatment mode, the reaction products upon heating mixtures are multiphase, but the main phase in all the cases is the Ti₃Cu₄ intermetallic compound, which, according to the reference data, has the highest negative enthalpy among binary intermetallic compounds. This fact of the determining effect of the thermodynamic factor on the phase composition of reaction products in mixtures of metal powders in systems with intermetallic compounds is consistent with the previously reported data on the titanium–nickel, titanium–iron, and titanium–aluminum systems, as well as on the titanium–aluminum–silicon ternary system. The possibility of using multiphase synthesis products in mixtures of titanium and copper powders to obtain metal-matrix titanium carbide–copper binder composites through the reaction with carbon has been substantiated.</p>