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Abstract <p>Recent advancements in systemic drug delivery emphasize the use of innovative technologies, such as pH-sensitive drug carriers, to achieve precise and efficient targeting within the body. These approaches hold significant promise for controlling drug delivery and guiding drugs to specific targets. This study investigates the fabrication of core-shell particles utilizing mesoporous vaterite particles coated with pH-sensitive alginate and cellulose. The research reveals that the formed coatings influence alterations in particle morphology and zeta potential, resulting in consistent pH-dependent release profiles. Furthermore, the negative potential reduces the uptake efficiency of the resulting particles into Raw 264.7 immune cells, demonstrating the potential for prolonged circulation time and increased bioavailability of the encapsulated substances. These findings underscore the potential efficacy of such systems for targeted drug delivery and their potential impact within the context of pH-sensitive drug delivery systems.</p>

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Effect of Shell Composition on the Internalization Efficiency of pH-Sensitive Drug Carriers Based on Mesoporous Particles

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • E. V. Lengert,
  • Yu. N. Vlasicheva,
  • A. O. Kuznetsov,
  • O. I. Guslyakova,
  • A. V. Ermakov

摘要

Abstract

Recent advancements in systemic drug delivery emphasize the use of innovative technologies, such as pH-sensitive drug carriers, to achieve precise and efficient targeting within the body. These approaches hold significant promise for controlling drug delivery and guiding drugs to specific targets. This study investigates the fabrication of core-shell particles utilizing mesoporous vaterite particles coated with pH-sensitive alginate and cellulose. The research reveals that the formed coatings influence alterations in particle morphology and zeta potential, resulting in consistent pH-dependent release profiles. Furthermore, the negative potential reduces the uptake efficiency of the resulting particles into Raw 264.7 immune cells, demonstrating the potential for prolonged circulation time and increased bioavailability of the encapsulated substances. These findings underscore the potential efficacy of such systems for targeted drug delivery and their potential impact within the context of pH-sensitive drug delivery systems.