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Abstract <p>The ability of Schiff bases derived from aromatic aldehydes ortho-substituted with a hydroxyl group to function as bidentate ligands for transitional metal ions initially piqued the curiosity of researchers. The dietary ingredient vanillin, which is present in plants naturally, is utilised to make Schiff base chelates. Para aminobenzoic derived analogues showed noticeable antifungal, antibacterial and antioxidant activities. In this work, the Schiff base ligand and a metal complex derived from vanillin and <i>para</i>-aminobenzoic acid were synthesized by microwave method and by reflux method. The complex and ligand were characterized by IR, mass spectroscopy, PXRD and elemental analysis. The anti-oxidant activity of the Zinc vanillin <i>para</i>-aminobenzoic acid metal complex was calculated using DPPH assay and obtained an IC 50 value of 33.11 µg/mL. The Antifungal activity of the ligand and its complex were tested and showed moderate activity against Candida Albicans.</p>

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Synthesis and Characterization of Vanillin Derived Schiff Base Metal Complex of Zinc and Its Anti-Oxidant and Antifungal Activity

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • V. Nayana Senan,
  • K. S. Beena Kumari,
  • O. Lekshmy

摘要

Abstract

The ability of Schiff bases derived from aromatic aldehydes ortho-substituted with a hydroxyl group to function as bidentate ligands for transitional metal ions initially piqued the curiosity of researchers. The dietary ingredient vanillin, which is present in plants naturally, is utilised to make Schiff base chelates. Para aminobenzoic derived analogues showed noticeable antifungal, antibacterial and antioxidant activities. In this work, the Schiff base ligand and a metal complex derived from vanillin and para-aminobenzoic acid were synthesized by microwave method and by reflux method. The complex and ligand were characterized by IR, mass spectroscopy, PXRD and elemental analysis. The anti-oxidant activity of the Zinc vanillin para-aminobenzoic acid metal complex was calculated using DPPH assay and obtained an IC 50 value of 33.11 µg/mL. The Antifungal activity of the ligand and its complex were tested and showed moderate activity against Candida Albicans.