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Abstract <p>This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of <i>N</i>-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine leads to alterations in the UV spectra of DNA. Furthermore, the antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity of <i>N</i>‑(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine was tested. The results show that the mentioned compound had higher antioxidant activity than previously reported comparison of <i>N</i>-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. Flow cytometry included analysis of the expression level of PD-L1 and TIM-3 in the presence of <i>N</i>-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine on HCT116 cell line.</p>

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Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • I. Chernov,
  • A. Protas,
  • E. Popova,
  • O. Mikolaichuk,
  • O. Shemchuk,
  • S. Tsymbal,
  • O. Molchanov,
  • D. Maistrenko

摘要

Abstract

This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine leads to alterations in the UV spectra of DNA. Furthermore, the antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity of N‑(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine was tested. The results show that the mentioned compound had higher antioxidant activity than previously reported comparison of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. Flow cytometry included analysis of the expression level of PD-L1 and TIM-3 in the presence of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine on HCT116 cell line.