Abstract <p>In the modern world, scientists often discuss problems associated with complications of pregnancy and childbirth in women. The study of cases of repeated fetal loss, stillbirth, intrauterine growth retardation, and preeclampsia leads to the discovery of new aspects of this pathology. In the last decade, an increasing number of studies have reported the presence of patients suffering from seronegative and noncriteria variants of antiphospholipid syndrome, who may have unconventional “noncriteria” antiphospholipid antibodies. Large prospective, multicenter, and multinational studies are needed to improve test standardization. When evaluating a patient with clinical manifestations consistent with obstetric antiphospholipid syndrome but negative serologic tests for standard antibodies, the physician should consider the possibility of developing noncriteria antiphospholipid syndrome. This review will highlight current trends in the identification of patients with reproductive failure associated with noncriteria antiphospholipid syndrome. A review of modern Russian and foreign, primarily English-language, literature devoted to noncriteria antiphospholipid syndrome was conducted. When writing, the latest publications in specialized medical journals and manuals were taken into account. In the future, pregnancy with noncriteria antiphospholipid syndrome will be one of the main tasks of obstetric research, and further developments in this area are needed to develop new therapeutic and preventive possibilities.</p>