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Abstract <p>This study characterizes extracellular vesicles (EVs) produced by multipotent mesenchymal stromal cells (MMSCs) in culture medium. The vesicles isolated by centrifugation contained proteins specific to exosomes and had a characteristic size. The effects of vesicles produced by MMSC (MMSC-EVs) on kidney cells under normal and pathological conditions were analyzed. MMSC-EVs increased the proliferation rate of renal epithelial cells after damage caused by oxygen-glucose deprivation. The microRNA expression profile in MMSC-EVs showed that both damage-aggravating and protective microRNAs were highly expressed in them. The overall effect of MMSC-EVs on kidney cells appears to result from the complex interactions of protein signals and the regulatory effects of microRNAs.</p>

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The Effect of Extracellular Vesicles Produced by MMSC on the Growth Rate of Cultured Renal Epithelial Cells under Normal Conditions and under Oxygen-Glucose Deprivation

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • A. K. Lomakina,
  • A. M. Yurin,
  • V. S. Chernyshov,
  • D. N. Silachev,
  • E. Y. Plotnikov,
  • I. B. Pevzner

摘要

Abstract

This study characterizes extracellular vesicles (EVs) produced by multipotent mesenchymal stromal cells (MMSCs) in culture medium. The vesicles isolated by centrifugation contained proteins specific to exosomes and had a characteristic size. The effects of vesicles produced by MMSC (MMSC-EVs) on kidney cells under normal and pathological conditions were analyzed. MMSC-EVs increased the proliferation rate of renal epithelial cells after damage caused by oxygen-glucose deprivation. The microRNA expression profile in MMSC-EVs showed that both damage-aggravating and protective microRNAs were highly expressed in them. The overall effect of MMSC-EVs on kidney cells appears to result from the complex interactions of protein signals and the regulatory effects of microRNAs.