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Abstract <p>Unnatural amino acids (UAAs) are powerful tools for investigating protein structure and dynamics. Their inclusion in a protein can help reveal important details about its functions and structural features, especially with respect to membrane proteins. However, efficient incorporation of UAAs into membrane proteins remains a challenge. In this review, we explore using <i>Leishmania tarentolae</i> (LEXSY) as a host system to express membrane proteins with incorporated UAAs, aiming to develop a versatile platform for future research and drug discovery.</p>

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Expanding the Genetic Code in Leishmania tarentolae: A Novel Platform for Membrane Protein Expression with Unnatural Amino Acids

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • I. S. Levashov,
  • I. A. Kapranov,
  • D. A. Kornilov,
  • P. K. Kuzmichev,
  • A. V. Mishin,
  • V. I. Borshchevskiy

摘要

Abstract

Unnatural amino acids (UAAs) are powerful tools for investigating protein structure and dynamics. Their inclusion in a protein can help reveal important details about its functions and structural features, especially with respect to membrane proteins. However, efficient incorporation of UAAs into membrane proteins remains a challenge. In this review, we explore using Leishmania tarentolae (LEXSY) as a host system to express membrane proteins with incorporated UAAs, aiming to develop a versatile platform for future research and drug discovery.