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Abstract <p><b>Objective:</b> To evaluate the evidence from randomized in vitro studies on the efficacy of <i>Boswellia serrata</i> (frankincense) extracts, a systematic search was conducted using keywords such as “frankincense,” or “Boswellia serrata,” and “cell culture” in databases including Web of Science, PubMed, Scopus, ScienceDirect, and Google Scholar. <b>Material and methods:</b> The checklist and recommendations of PRISMA were used to design this systematic review. <b>Results and discussion:</b> All in vitro studies of frankincense extract were included, while other frankincense preparation studies and review articles were excluded. Out of 64 potentially relevant studies, 18 met all inclusion criteria. These in vitro studies examined the effects of frankincense on human and animal cell cultures. The results indicated that frankincense extracts were effective in terms of efficacy. Four studies were of relatively good methodological quality. <b>Conclusions:</b> While the reports and documentation on the effectiveness of frankincense extract are promising, they are not yet convincing or sufficient.</p>

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A Systematic Review of Frankincense’s Impact on Human and Animal Cells In Vitro

  • 期刊论文

  • 发表日期：

    2025年2月10日

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  • Mojtaba Esmaeli,
  • Maryam Dehghanpour Dehabadi,
  • Mahdi Barazesh,
  • Ali Ghanbari

摘要

Abstract

Objective: To evaluate the evidence from randomized in vitro studies on the efficacy of Boswellia serrata (frankincense) extracts, a systematic search was conducted using keywords such as “frankincense,” or “Boswellia serrata,” and “cell culture” in databases including Web of Science, PubMed, Scopus, ScienceDirect, and Google Scholar. Material and methods: The checklist and recommendations of PRISMA were used to design this systematic review. Results and discussion: All in vitro studies of frankincense extract were included, while other frankincense preparation studies and review articles were excluded. Out of 64 potentially relevant studies, 18 met all inclusion criteria. These in vitro studies examined the effects of frankincense on human and animal cell cultures. The results indicated that frankincense extracts were effective in terms of efficacy. Four studies were of relatively good methodological quality. Conclusions: While the reports and documentation on the effectiveness of frankincense extract are promising, they are not yet convincing or sufficient.