Scholarlink

<p>Post-stroke cognitive impairment is a significant contributor to disability in people who have had ischemic stroke (IS). Previously, it was shown that the study of the composition of small extracellular vesicles and related functions provides new opportunities for diagnosing post-stroke cognitive impairment. The aim of this work was to compare the proteins of L1CAM-positive extracellular vesicles from serum of patients with different cognitive status in the acute period of IS. A comparative quantitative proteomic analysis of L1CAM-positive extracellular vesicles of patients without cognitive impairment (8, mean age 61.8 ± 14.1 years) and patients with moderate cognitive impairment (MCI) (8, mean age 61.8 ± 14.1 years) revealed significant differences in the levels of 10 proteins out of 131 identified proteins. Patients with MCI, compared to patients without MCI, had reduced levels of proteins associated with the immune system in the acute post-stroke period.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Cognitive Status of Patients after Ischemic Stroke is Associated with the Levels of Cytoplasmic Actin 1 and Some Immunoglobulins in L1cam-Positive Extracellular Vesicles of Blood Serum

  • 期刊论文

  • 发表日期：

    2025年9月1日

查看全文
  • M. Yu. Zhanina,
  • T. A. Druzhkova,
  • E. E. Vladimirova,
  • A. B. Guekht,
  • N. V. Gulyaeva

摘要

Post-stroke cognitive impairment is a significant contributor to disability in people who have had ischemic stroke (IS). Previously, it was shown that the study of the composition of small extracellular vesicles and related functions provides new opportunities for diagnosing post-stroke cognitive impairment. The aim of this work was to compare the proteins of L1CAM-positive extracellular vesicles from serum of patients with different cognitive status in the acute period of IS. A comparative quantitative proteomic analysis of L1CAM-positive extracellular vesicles of patients without cognitive impairment (8, mean age 61.8 ± 14.1 years) and patients with moderate cognitive impairment (MCI) (8, mean age 61.8 ± 14.1 years) revealed significant differences in the levels of 10 proteins out of 131 identified proteins. Patients with MCI, compared to patients without MCI, had reduced levels of proteins associated with the immune system in the acute post-stroke period.