Abstract <p>This study aims to investigate the levels of pleiotrophin (PTN) in patients with aneurysmal subarachnoid hemorrhage (SAH) and to explore its potential role in inflammatory responses and neuroprotective mechanisms. We conducted a comparative analysis of serum PTN levels between 40 patients diagnosed with aneurysmal SAH and 40 healthy controls matched for age and gender. Clinical parameters, including the GCS and WFNS score, the presence of vasospasm, and mortality outcomes, were also assessed in relation to PTN levels. Our findings indicated that PTN levels were significantly lower in the aneurysm patient group compared to healthy controls, suggesting a potential link between PTN reduction and the pathophysiological changes associated with SAH. Despite the assessment of various clinical parameters, we found no significant correlation between these factors and PTN levels, indicating that changes in clinical scores may not directly influence PTN levels. The study highlights the importance of PTN in the context of aneurysmal SAH, as its reduction may reflect inflammatory responses and neuroprotective mechanisms. Given the observed decline in PTN levels, further research is warranted to elucidate its specific role in neuronal health and recovery. Monitoring PTN levels over extended periods and conducting more comprehensive studies will be essential to enhancing its clinical significance as a biomarker. Ultimately, this research could inform personalized treatment strategies aimed at improving outcomes for patients with aneurysmal SAH.</p>