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Abstract <p>In this work, two new compounds, <i>N</i><sup>6</sup>-(4,5-dimethoxyphenyl)adenine and <i>N</i><sup>6</sup>-(3,5-di-trifluoromethylphenyl)adenine, with a broad range of antiviral activity against RNA viruses were identified. We showed that these compounds exhibit pronounced antiviral activity against human poliovirus types 1, 2, and 3, belonging to enterovirus C species. Both compounds also demonstrated pronounced antiviral activity against Coxsackie viruses B3, B5, and B6, belonging to enterovirus B species. In addition, the compounds demonstrated antiviral activity against Newcastle disease virus, which belongs to the paramyxovirus genus. The compounds discovered in this work can subsequently serve as prototypes for the development of new antiviral drugs against epidemiologically significant human RNA viruses.</p>

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New N6-Substituted Adenine Derivatives with High Antiviral Activity against RNA-Containing Viruses

  • 期刊论文

  • 发表日期：

    2025年1月22日

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  • A. A. Zenchenko,
  • Yu. D. Semenova,
  • E. R. Naberezhnaya,
  • Ya. D. Gumennaya,
  • A. V. Lipatova,
  • V. E. Oslovsky

摘要

Abstract

In this work, two new compounds, N6-(4,5-dimethoxyphenyl)adenine and N6-(3,5-di-trifluoromethylphenyl)adenine, with a broad range of antiviral activity against RNA viruses were identified. We showed that these compounds exhibit pronounced antiviral activity against human poliovirus types 1, 2, and 3, belonging to enterovirus C species. Both compounds also demonstrated pronounced antiviral activity against Coxsackie viruses B3, B5, and B6, belonging to enterovirus B species. In addition, the compounds demonstrated antiviral activity against Newcastle disease virus, which belongs to the paramyxovirus genus. The compounds discovered in this work can subsequently serve as prototypes for the development of new antiviral drugs against epidemiologically significant human RNA viruses.