Abstract <p>This study investigates proton-induced reactions on enriched selenium targets, focusing on the production of bromine radioisotopes, which are of significant medical relevance for both diagnostic imaging and therapeutic applications. The study employs Monte Carlo samples to evaluate for experimental uncertainty in energy and cross-section simulations, then enters corrected energy into TALYS 2.0 and compares corrected cross-sections to predictions. The relative variance technique was used for assessing experimental data from the EXFOR database using nuclear level density models that are included of the TALYS 2.0 code. The results demonstrated that the ⁷⁷Se(<i>p</i>,2<i>n</i>)⁷⁶Br and ⁷⁸Se(<i>p</i>,2<i>n</i>)⁷⁷Br reactions are among the most significant production routes, yielding 224.4 and 284.1 mCi/(µA h), respectively, with radionuclidic purities of 96.8 and 85.5%. The CTM and TGHFB models exhibited the lowest relative variance in both reactions, despite the SHFB being the best model in several of the reactions under study. According to our findings, the statistical analysis procedure is a practical tool that processes cross-section and energy ranges of nuclear reaction accuracy to reduce uncertainty in calculations, hence facilitating new applications in nuclear research and medicine.</p>