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Abstract <p>The search for production of innovative radioisotopes for medical applications is linked to advances in multimodal imaging techniques like PET/MRI that utilize two different physical processes simultaneously to achieve more accurate diagnostic image information. Manganese is an essential element involved as an adjuvant agent in many nuclear imaging techniques. In this study, manganese-52<i>m</i> + <i>g</i>(<sup>52<i>m</i></sup> <sup>+</sup> <sup><i>g</i></sup>Mn) production cross section was simulated by TALYS code via low-energy proton beam up to 15 MeV according to Razavi Hospital cyclotron in Mashhad. The proper thickness of chromium-52 (<sup>52</sup>Cr) target under (<i>p</i>, <i>n</i>) reaction was calculated by SRIM code. Then, <sup>52<i>m</i></sup> <sup>+</sup> <sup><i>g</i></sup>Mn production yield was normalized to 80 µA beam current and irradiation time. Also, <sup>53/54</sup>Cr(<i>p</i>, <i>n</i>)<sup>53/54</sup>Mn reactions cross sections were evaluated as rival reactions. The computed projected ranges for <sup>52/53/54</sup>Cr were 556.69, 567.44, and 578.15 µm, respectively, to determine the minimum target thickness under proton irradiation at 15 MeV. Additionally, the maximum cross section of (<i>p</i>, <i>n</i>) reaction was calculated to be 138 mb at 14 MeV proton energy through Pade approximation in curve fitting. At this energy, the production yield and saturation yield were estimated to be 8.93 and 1.73E + 3 MBq/µA.h, correspondingly. The selection of an expedient energy of the incident particle and also the design of an appropriate target depends on the local and economic conditions for the production of <sup>52<i>g</i></sup> <sup>+</sup> <sup><i>m</i></sup>Mn radioisotope.</p>

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Simulation of 52m + gMn Production Yield via Chromium Target under Low-Energy Proton Irradiation from Mashhad Small Cyclotron

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • A. Khorshidi,
  • M. Shams-Abadi

摘要

Abstract

The search for production of innovative radioisotopes for medical applications is linked to advances in multimodal imaging techniques like PET/MRI that utilize two different physical processes simultaneously to achieve more accurate diagnostic image information. Manganese is an essential element involved as an adjuvant agent in many nuclear imaging techniques. In this study, manganese-52m + g(52m + gMn) production cross section was simulated by TALYS code via low-energy proton beam up to 15 MeV according to Razavi Hospital cyclotron in Mashhad. The proper thickness of chromium-52 (52Cr) target under (p, n) reaction was calculated by SRIM code. Then, 52m + gMn production yield was normalized to 80 µA beam current and irradiation time. Also, 53/54Cr(p, n)53/54Mn reactions cross sections were evaluated as rival reactions. The computed projected ranges for 52/53/54Cr were 556.69, 567.44, and 578.15 µm, respectively, to determine the minimum target thickness under proton irradiation at 15 MeV. Additionally, the maximum cross section of (p, n) reaction was calculated to be 138 mb at 14 MeV proton energy through Pade approximation in curve fitting. At this energy, the production yield and saturation yield were estimated to be 8.93 and 1.73E + 3 MBq/µA.h, correspondingly. The selection of an expedient energy of the incident particle and also the design of an appropriate target depends on the local and economic conditions for the production of 52g + mMn radioisotope.