Scholarlink

Abstract <p>A facile synthesis of a biologically significant fused heterocyclic system comprising benzimidazole and 1,6-naphthyridine is described. The synthetic approach involves three reactions: Suzuki coupling, imidazole construction, and C–N cross-coupling. The Suzuki coupling of 2-chloro-3-formylquinolines with (2-bromo­phenyl)boronic acid, followed by condensation with 1,2-diaminoarenes and subsequent palladium-catalyzed C–N cross-coupling, afforded benzimidazonaphthyridines, a privileged heterocyclic scaffold. The strengths of the protocol include the ready availability of the precursors, simple procedures, and good yields.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Feasible Synthesis of Benzimidazonaphthyridines Involving Suzuki and C–N Cross-Coupling Reactions

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • B. Padma,
  • P. K. Rathod,
  • P. Leelavathi

摘要

Abstract

A facile synthesis of a biologically significant fused heterocyclic system comprising benzimidazole and 1,6-naphthyridine is described. The synthetic approach involves three reactions: Suzuki coupling, imidazole construction, and C–N cross-coupling. The Suzuki coupling of 2-chloro-3-formylquinolines with (2-bromo­phenyl)boronic acid, followed by condensation with 1,2-diaminoarenes and subsequent palladium-catalyzed C–N cross-coupling, afforded benzimidazonaphthyridines, a privileged heterocyclic scaffold. The strengths of the protocol include the ready availability of the precursors, simple procedures, and good yields.