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Abstract <p>Reactions of difluoroacetyl- and trifluoroacetylpyruvaldehyde dimethyl acetals with methyl and phenylhydrazine in methanol occur regioselectively and make it possible to obtain <i>N-</i>methyl- and <i>N-</i>phenyl-substituted 5-polyfluoromethylpyrazole-3-carbaldehydes and their dimethyl acetals in good yields. Regioisomeric <i>N-</i>methyl- and <i>N-</i>phenyl-substituted 3-polyfluoromethylpyrazole-5-carbaldehydes and their dimethyl acetals were synthesized in moderate yields by reacting the same reagents in trifluoroethanol or acetic acid.</p>

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Features of Synthesis of 5(3)-Polyfluoromethylpyrazole-3(5)-carbaldehydes and Their Dimethyl Acetals

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • D. V. Belyaev,
  • D. L. Chizhov,
  • G. L. Rusinov,
  • V. N. Charushin

摘要

Abstract

Reactions of difluoroacetyl- and trifluoroacetylpyruvaldehyde dimethyl acetals with methyl and phenylhydrazine in methanol occur regioselectively and make it possible to obtain N-methyl- and N-phenyl-substituted 5-polyfluoromethylpyrazole-3-carbaldehydes and their dimethyl acetals in good yields. Regioisomeric N-methyl- and N-phenyl-substituted 3-polyfluoromethylpyrazole-5-carbaldehydes and their dimethyl acetals were synthesized in moderate yields by reacting the same reagents in trifluoroethanol or acetic acid.