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Abstract <p>This study presents the synthesis of a series of novel N-substituted 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamides <b>6a</b>–<b>6j</b>. The process begins with the preparation of 2,4-substituted thiazole-5-carboxylate <b>3</b>, followed by its hydrolysis using sodium hydroxide. The resulting intermediate, 2,4-substituted thiazole-5-carboxylic acid <b>4</b>, is then reacted with various aromatic and heterocyclic amines <b>5</b> in an appropriate solvent in the presence of EDC·HCl and a catalytic amount of DMAP. This method is environmentally friendly and cost-effective. The synthesized thiazole derivatives were characterized using advanced spectroscopic techniques, including mass spectrometry and IR and <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy.</p>

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An Efficient Synthesis of Novel 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamides

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • A. Bodkhe,
  • D. Pansare,
  • D. Karpe,
  • V. Sudrik,
  • M. Suryawanshi,
  • R. Shinde,
  • S. Lawande

摘要

Abstract

This study presents the synthesis of a series of novel N-substituted 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamides 6a–6j. The process begins with the preparation of 2,4-substituted thiazole-5-carboxylate 3, followed by its hydrolysis using sodium hydroxide. The resulting intermediate, 2,4-substituted thiazole-5-carboxylic acid 4, is then reacted with various aromatic and heterocyclic amines 5 in an appropriate solvent in the presence of EDC·HCl and a catalytic amount of DMAP. This method is environmentally friendly and cost-effective. The synthesized thiazole derivatives were characterized using advanced spectroscopic techniques, including mass spectrometry and IR and 1H and 13C NMR spectroscopy.