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Abstract <p>A Ni-Pd complex catalyst with superior catalytic performance was successfully synthesized via coordination reactions between nickel and palladium salts and ethylene glycol dimethyl ether as the ligand. A series of 38 biaryl derivatives were efficiently synthesized through the Suzuki coupling reaction by using the new Ni–Pd complex catalyst. This synthetic protocol offers several advantages, including mild reaction condi­tions, low catalyst cost, and facile scalability, making it highly attractive for practical applications. Notably, under ambient temperature, liquid crystal monomer materials, 2-cyano-4′-methylbiphenyl and ethyl biphenyl­acetate, were efficiently synthesized with excellent yields exceeding 95%, and 2-(4-fluorophenyl)thiophene was synthesized in 83% yield. The catalyst cost for preparing the same amount of products using the new complex catalyst was only 8% of that required with the conventional Pd(PPh<sub>3</sub>)<sub>4</sub> catalyst, highlighting the economic and synthetic advantages of the new system.</p>

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Synthesis of a New Nickel–Palladium Complex Catalyst and Its Application in Suzuki-Miyaura Reaction

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • Le-Quan Wang,
  • Shang-Chuang Liang,
  • Kai-Yu Mei,
  • Jie Li,
  • Zi-Wei Xi,
  • Hong-Yu Huang,
  • Yong-Miao Shen

摘要

Abstract

A Ni-Pd complex catalyst with superior catalytic performance was successfully synthesized via coordination reactions between nickel and palladium salts and ethylene glycol dimethyl ether as the ligand. A series of 38 biaryl derivatives were efficiently synthesized through the Suzuki coupling reaction by using the new Ni–Pd complex catalyst. This synthetic protocol offers several advantages, including mild reaction condi­tions, low catalyst cost, and facile scalability, making it highly attractive for practical applications. Notably, under ambient temperature, liquid crystal monomer materials, 2-cyano-4′-methylbiphenyl and ethyl biphenyl­acetate, were efficiently synthesized with excellent yields exceeding 95%, and 2-(4-fluorophenyl)thiophene was synthesized in 83% yield. The catalyst cost for preparing the same amount of products using the new complex catalyst was only 8% of that required with the conventional Pd(PPh3)4 catalyst, highlighting the economic and synthetic advantages of the new system.