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Abstract <p>4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1 : 2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-[2-(3-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1<i>H</i>-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-[2-(4-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1<i>H</i>-pyrazole-5-carboxylic acids. The structure of the products was confirmed by X-ray diffraction analysis. The reaction proceeds under mild, catalyst-free conditions to give high yields, and the products were isolated without column chromatography. The synthesized compounds exhibit potential for diverse biological activities.</p>

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Reaction of Aroylpyruvic Acids with 3- and 4-Nitrobenzohydrazides. Synthesis of Pyrazoline-5-carboxylic Acids

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. A. Andreeva,
  • Yu. V. Shklyaev,
  • A. N. Maslivets

摘要

Abstract

4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1 : 2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-[2-(3-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-[2-(4-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids. The structure of the products was confirmed by X-ray diffraction analysis. The reaction proceeds under mild, catalyst-free conditions to give high yields, and the products were isolated without column chromatography. The synthesized compounds exhibit potential for diverse biological activities.