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Abstract <p>In the present study, we have developed a Baker’s yeast (BY) mediated efficient and mild nitration of aromatic compounds. The results of nitration clearly showed that it is a highly regio-selective method, when aromatic compounds (<b>1a</b>–<b>1h</b>) were nitrated by using the BY/nitric acid system and gave corresponding nitro derivatives (<b>2a</b>–<b>2h</b>) in good to excellent yield. The present reaction condition is advantageous as it follows a normal procedure and requires a simple workup, adhering to green chemistry principles. Thus, we can conclude that the present nitration method is a simple, efficient, regio-selective, and eco-friendly method under bio-catalysis conditions.</p>

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Baker’s Yeast Mediated Efficient and Mild Nitration of Aromatic Compounds

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Qasim Ullah,
  • Aarifa Maryam,
  • Samreen Kausar,
  • Mohammed Arifuddin

摘要

Abstract

In the present study, we have developed a Baker’s yeast (BY) mediated efficient and mild nitration of aromatic compounds. The results of nitration clearly showed that it is a highly regio-selective method, when aromatic compounds (1a–1h) were nitrated by using the BY/nitric acid system and gave corresponding nitro derivatives (2a–2h) in good to excellent yield. The present reaction condition is advantageous as it follows a normal procedure and requires a simple workup, adhering to green chemistry principles. Thus, we can conclude that the present nitration method is a simple, efficient, regio-selective, and eco-friendly method under bio-catalysis conditions.