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Abstract <p>A preparative method has been developed for the synthesis of previously unknown 3,3,4-trihydroxy­benzimidazo[2,1-<i>b</i>][1,3]thiazinium salts in up to 93% yield by the microwave-assisted reaction of chloro oxiranes and chloro ketones containing an acetal moiety with 1-ethyl-1<i>H</i>-benzimidazole-2-thiol in 95% ethanol. The synthesized compounds are of interest for medicinal chemistry.</p>

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New Synthesis of Aryl-Substituted 3,3,4-Trihydroxy-2,3,4,10-tetrahydrobenzo[4,5]imidazo[2,1-b][1,3]thiazinium Salts

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • F. I. Guseinov,
  • L. M. Kustov,
  • K. A. Afanasyeva,
  • E. V. Shuvalova,
  • K. I. Kobrakov,
  • Yu. L. Sebyakin,
  • A. V. Stepanov,
  • A. I. Samigullina

摘要

Abstract

A preparative method has been developed for the synthesis of previously unknown 3,3,4-trihydroxy­benzimidazo[2,1-b][1,3]thiazinium salts in up to 93% yield by the microwave-assisted reaction of chloro oxiranes and chloro ketones containing an acetal moiety with 1-ethyl-1H-benzimidazole-2-thiol in 95% ethanol. The synthesized compounds are of interest for medicinal chemistry.