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Abstract <p>A new strategy for one-pot synthesis of quaternary phosphonium salts with an ester group was developed and applied to obtain previously unknown a series phosphonium salts by reacting triphenylphosphine with halocarboxylic acids in an alcoholic medium. The alkylation of carboxylate phosphabetaines with alcohols in an acidic medium was studied. The structures and compositions of all synthesized compounds were confirmed by IR and <sup>31</sup>P and <sup>13</sup>C NMR spectroscopy and elemental analysis. The structure of the phosphonium salts was verified using single-crystal X-ray diffraction analysis. In vitro antimicrobial screening showed that the synthesized phosphonium salts exhibited notable inhibition zones against Gram-positive strains.</p>

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New Strategy for One-Pot Synthesis of Antimicrobial Quaternary Phosphonium Salts with an Ester Group

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • S. R. Romanov,
  • P. P. Andreeva,
  • M. P. Shulaeva,
  • O. K. Pozdeev,
  • A. P. Fedonin,
  • O. N. Kataeva,
  • I. V. Galkina,
  • Y. V. Bakhtiyarova

摘要

Abstract

A new strategy for one-pot synthesis of quaternary phosphonium salts with an ester group was developed and applied to obtain previously unknown a series phosphonium salts by reacting triphenylphosphine with halocarboxylic acids in an alcoholic medium. The alkylation of carboxylate phosphabetaines with alcohols in an acidic medium was studied. The structures and compositions of all synthesized compounds were confirmed by IR and 31P and 13C NMR spectroscopy and elemental analysis. The structure of the phosphonium salts was verified using single-crystal X-ray diffraction analysis. In vitro antimicrobial screening showed that the synthesized phosphonium salts exhibited notable inhibition zones against Gram-positive strains.