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Abstract <p>The reaction of N-methylated nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. Subsequent interaction of this salt with S-, O-, and N-nucleophiles gave functionalized derivatives of nimesulide.</p>

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Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-dimethylisoxazol-4-yl)iodonium Salt Formation

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • D. I. Bugaenko,
  • A. V. Karchava

摘要

Abstract

The reaction of N-methylated nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. Subsequent interaction of this salt with S-, O-, and N-nucleophiles gave functionalized derivatives of nimesulide.