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Abstract <p>Ethyl esters of 4-spiro-fused 6,7-dimethoxydihydroisoquinoline-1-carboxylatic acids were reduced to the corresponding 1-(hydroxymethyl)tetrahydroisoquinolines. The latter were cyclized with Formalin to form oxazoloisoquinolines, which were then recyclized into tetrahydropyranoisoquinolines by treatment with hydrobromic and concentrated hydrochloric acids. Spiro-fused 1-(hydroxymethyl)isoquinoline-6,7-diols were reacted with dibromoethane to obtain the corresponding dioxinoisoquinolines.</p>

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Synthesis of Novel Fused Systems Derived from 4-Spiro-Fused 6,7-Dimethoxy-1-(ethoxycarbonyl)dihydroisoquinolines

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. A. Aghekyan,
  • H. A. Panosyan,
  • A. S. Avagyan

摘要

Abstract

Ethyl esters of 4-spiro-fused 6,7-dimethoxydihydroisoquinoline-1-carboxylatic acids were reduced to the corresponding 1-(hydroxymethyl)tetrahydroisoquinolines. The latter were cyclized with Formalin to form oxazoloisoquinolines, which were then recyclized into tetrahydropyranoisoquinolines by treatment with hydrobromic and concentrated hydrochloric acids. Spiro-fused 1-(hydroxymethyl)isoquinoline-6,7-diols were reacted with dibromoethane to obtain the corresponding dioxinoisoquinolines.