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Abstract <p>6-(2-Bromoethyl)-6<i>H</i>-indolo[2,3-<i>b</i>]quinoxaline was synthesized and reacted with arylamines to obtain <i>N</i>-(2-[6<i>H</i>-indolo[2,3-<i>b</i>]quinoxalin-6-yl)ethyl]arylamines and <i>N</i>,<i>N</i>-disubstituted 4-methylaniline. Previosly unknown 6-vinyl- and 6-(2-azidoethyl) derivatives of 6-(2-bromoethyl)-6<i>H</i>-indolo[2,3-<i>b</i>]quinoxaline and indolo[2,3-<i>b</i>]quinoxaline–pyrimidine and 1,2-bis(6<i>H</i>-indolo[2,3-<i>b</i>]quinoxalin-6-yl)ethane hybrids were also synthesized. Molecular docking studies of the synthesized indolo[2,3-b]quinoxaline derivatives against 4 different receptors indicated high predicted activity for the indoloquinoxaline–pyrimidine conjugate.</p>

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Synthesis and Docking Study of 6-Substituted Indolo[2,3-b]quinoxalines

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • A. A. Harutyunyan,
  • A. S. Sumbatyan,
  • S. G. Israelyan,
  • A. A. Hambardzumyan,
  • H. А. Panosyan

摘要

Abstract

6-(2-Bromoethyl)-6H-indolo[2,3-b]quinoxaline was synthesized and reacted with arylamines to obtain N-(2-[6H-indolo[2,3-b]quinoxalin-6-yl)ethyl]arylamines and N,N-disubstituted 4-methylaniline. Previosly unknown 6-vinyl- and 6-(2-azidoethyl) derivatives of 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline and indolo[2,3-b]quinoxaline–pyrimidine and 1,2-bis(6H-indolo[2,3-b]quinoxalin-6-yl)ethane hybrids were also synthesized. Molecular docking studies of the synthesized indolo[2,3-b]quinoxaline derivatives against 4 different receptors indicated high predicted activity for the indoloquinoxaline–pyrimidine conjugate.