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Abstract <p>A series of new thiazole derivatives containing quinoline moieties were synthesized in two step reactions as the study of potential antimicrobial and antioxidant activities. All synthesized compounds were characterized by IR, <sup>1</sup>H, <sup>13</sup>C NMR, HMBC, and HSQC spectral techniques and elemental analysis. In antimicrobial and antioxidant studies, compound <b>2b</b> displayed remarkable activity with highest inhibition value 28 ± 0.5 mm against <i>S. typhimurium</i> and showed significant antioxidant activity with IC<sub>50</sub> value 28.49 ± 1.3 µg/mL as compared to the standard Ascorbic acid (IC<sub>50</sub> 49.67 ± 3.38 µg/mL). Molecular docking studies also agreed with significant basis for antimicrobial and antioxidant activities.</p>

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Synthesis, Bioactivity Screening, and Molecular Docking Studies of Some New Thiazole Derivatives Containing Quinoline Moieties

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Md. Mohiuddin Emon,
  • Md. Abu Bakkar Siddiki,
  • Md. Din Islam,
  • Aongchainu Marma,
  • Ranajit Kumar Sutradhar

摘要

Abstract

A series of new thiazole derivatives containing quinoline moieties were synthesized in two step reactions as the study of potential antimicrobial and antioxidant activities. All synthesized compounds were characterized by IR, 1H, 13C NMR, HMBC, and HSQC spectral techniques and elemental analysis. In antimicrobial and antioxidant studies, compound 2b displayed remarkable activity with highest inhibition value 28 ± 0.5 mm against S. typhimurium and showed significant antioxidant activity with IC50 value 28.49 ± 1.3 µg/mL as compared to the standard Ascorbic acid (IC50 49.67 ± 3.38 µg/mL). Molecular docking studies also agreed with significant basis for antimicrobial and antioxidant activities.