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Abstract <p>Amberlyst A21, a solid ion-exchange resin, is known as a practical and recyclable catalyst for the synthesis of Hantzsch polyhydroquinolines providing an environmentally friendly option to produce pharmaceutically significant polyhydroquinoline derivatives. The present research illustrates the effective utilization of Amberlyst A21 for a one-pot, multicomponent reaction that includes aldehyde, ethyl acetoacetate, dimedone and ammonium acetate under ultrasonic irradiation at room temperature. The method significantly enhances the reaction rate and product yield, providing high yields without hazardous solvents or chromatographic purification. The catalyst’s recyclability and environmental compatibility make it an attractive choice for sustainable organic synthesis. The synthesis process is optimized by evaluating various solvents and catalyst loadings, demonstrating its potential for industrial-scale applications. Overall, this work contributes to the ongoing development of green chemistry in pharmaceutical research by providing an economical, efficient, and environmentally friendly method for synthesizing polyhydroquinoline derivatives.</p>

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Amberlyst A21 as a Recyclable Solid Catalyst for a Green Hantzsch Polyhydroquinoline Synthesis

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Kalpana M. Tekale,
  • Pooja R. Saste,
  • Santosh S. Katkar

摘要

Abstract

Amberlyst A21, a solid ion-exchange resin, is known as a practical and recyclable catalyst for the synthesis of Hantzsch polyhydroquinolines providing an environmentally friendly option to produce pharmaceutically significant polyhydroquinoline derivatives. The present research illustrates the effective utilization of Amberlyst A21 for a one-pot, multicomponent reaction that includes aldehyde, ethyl acetoacetate, dimedone and ammonium acetate under ultrasonic irradiation at room temperature. The method significantly enhances the reaction rate and product yield, providing high yields without hazardous solvents or chromatographic purification. The catalyst’s recyclability and environmental compatibility make it an attractive choice for sustainable organic synthesis. The synthesis process is optimized by evaluating various solvents and catalyst loadings, demonstrating its potential for industrial-scale applications. Overall, this work contributes to the ongoing development of green chemistry in pharmaceutical research by providing an economical, efficient, and environmentally friendly method for synthesizing polyhydroquinoline derivatives.