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Abstract <p>5-Substituted-1<i>H</i>-tetrazoles can be synthesized from the corresponding nitriles by reaction with NaN<sub>3</sub> using the efficient and green onion extract catalyst under microwave irradiation and solvent- free conditions in good to excellent yields (up to 95%) and very short reaction times. This method is applicable to a wide range of aryl and alkyl nitriles with sodium azide in solvent-free media, and affords the various tetrazole derivatives in an eco-friendly solvent-less procedure under microwave irradiation at reaction temperature 120°C. The use of onion extract makes the process environmentally benign.</p>

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MW-Induced Solvent-Free Synthesis of 5-Substituted 1H-Tetrazoles Using Onion (Allium cepa L.) Extract as an Eco-friendly and Green Catalyst

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • O. Marvi,
  • B. Baghernejad

摘要

Abstract

5-Substituted-1H-tetrazoles can be synthesized from the corresponding nitriles by reaction with NaN3 using the efficient and green onion extract catalyst under microwave irradiation and solvent- free conditions in good to excellent yields (up to 95%) and very short reaction times. This method is applicable to a wide range of aryl and alkyl nitriles with sodium azide in solvent-free media, and affords the various tetrazole derivatives in an eco-friendly solvent-less procedure under microwave irradiation at reaction temperature 120°C. The use of onion extract makes the process environmentally benign.