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Abstract <p>A series of fluorinated pyrazoles was synthesized in a straightforward manner without the use of hazardous catalysts, toxic solvents, or extreme reaction conditions, yielding high product efficiency. Fluorinated aldehyde and piperonal underwent a condensation reaction to form a chalcone intermediate, which was subsequently cyclized with hydrazine hydrate to yield the corresponding pyrazole derivatives. The structures of the synthesized compounds were confirmed using IR, <sup>1</sup>H NMR, and mass spectrometry. These compounds were then evaluated for their antibacterial and antitubercular activity. Molecular docking studies revealed high binding affinity scores across the entire series.</p>

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Synthesis of Pyrrole-Based Heterocycles Containing a Trifluoromethyl Group: Their Characterization, Biological Evaluation, and Docking Study

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • G. Shingare,
  • D. Mundhe,
  • A. Sapkal,
  • V. Talati,
  • B. Madje,
  • J. Chamargore

摘要

Abstract

A series of fluorinated pyrazoles was synthesized in a straightforward manner without the use of hazardous catalysts, toxic solvents, or extreme reaction conditions, yielding high product efficiency. Fluorinated aldehyde and piperonal underwent a condensation reaction to form a chalcone intermediate, which was subsequently cyclized with hydrazine hydrate to yield the corresponding pyrazole derivatives. The structures of the synthesized compounds were confirmed using IR, 1H NMR, and mass spectrometry. These compounds were then evaluated for their antibacterial and antitubercular activity. Molecular docking studies revealed high binding affinity scores across the entire series.