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Abstract <p>Naphthalene-bridged pyrazole scaffolds are important as fundamental components in numerous pharmacologically active novel chemical entities. The present study focuses on the synthesis of derivatives of <i>N</i>-((2-hydroxynaphthalen-1-yl)(1<i>H</i>-pyrazol-5-yl)methyl)acetamides (<b>4</b>). This synthesis was achieved through a one-pot three-component reaction involving naphthalen-2-ol (<b>1</b>), 1<i>H</i>-pyrazole-5-carbaldehydes (<b>2</b>), and acetamides (<b>3</b>). The reaction was conducted using [BMIM][BF<sub>4</sub>] as a green reaction medium, producing good yields of the desired products. The compounds <b>4b</b>, <b>4c</b>, and <b>4d</b> showed similar amino acid interaction with Thr 179 and docking scores of –7.839, –8.021, and –8.446 with 5LYJ.pdb. The compound <b>4f</b> showed interaction with Tyr 281 and a docking score of –7.293 with 6WV3.pdb.</p>

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[BMIM]BF4-Mediated Multicomponent Synthesis of N-[(2-Hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl]acetamides

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Pullagura Siva Prakash,
  • Vidavalur Siddhaiah,
  • Arunkumar Thiriveedhi,
  • A. Sajeli Begum,
  • Lakshmi Soukya,
  • Venkateswara Rao B,
  • Akula Raghunadh,
  • and Podugu Rajitha Lakshmi

摘要

Abstract

Naphthalene-bridged pyrazole scaffolds are important as fundamental components in numerous pharmacologically active novel chemical entities. The present study focuses on the synthesis of derivatives of N-((2-hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl)acetamides (4). This synthesis was achieved through a one-pot three-component reaction involving naphthalen-2-ol (1), 1H-pyrazole-5-carbaldehydes (2), and acetamides (3). The reaction was conducted using [BMIM][BF4] as a green reaction medium, producing good yields of the desired products. The compounds 4b, 4c, and 4d showed similar amino acid interaction with Thr 179 and docking scores of –7.839, –8.021, and –8.446 with 5LYJ.pdb. The compound 4f showed interaction with Tyr 281 and a docking score of –7.293 with 6WV3.pdb.