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Abstract <p>An efficient, one-pot, and metal-free catalytic synthesis of β-keto sulfones was developed through the oxidative sulfonylation of enol acetates with readily available sodium sulfinates. The protocol involves tetrabutylammonium iodide (TBAI) as a catalyst and <i>tert</i>-butyl hydroperoxide (TBHP) as an oxidant at 60°C. The developed protocol offers such advantages as the use of commercially available inexpensive catalysts and oxidants and safe and environmentally benign conditions, and it provides a facile and mild access to a variety of β-keto sulfones.</p>

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Tetrabutylammonium Iodide-Catalyzed Oxidative Coupling of Enol Acetates with Sodium Sulfinates: A Mild Access to β-Keto Sulfones

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Babita Yadav

摘要

Abstract

An efficient, one-pot, and metal-free catalytic synthesis of β-keto sulfones was developed through the oxidative sulfonylation of enol acetates with readily available sodium sulfinates. The protocol involves tetrabutylammonium iodide (TBAI) as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant at 60°C. The developed protocol offers such advantages as the use of commercially available inexpensive catalysts and oxidants and safe and environmentally benign conditions, and it provides a facile and mild access to a variety of β-keto sulfones.