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Abstract <p>A simple and practical method of synthesis of a new series of functionalized isoxazole/isoxazoline styrylchromone derivatives from 3-hydroxy-2-styrylchromone <i>via</i> an alkene/alkyne-tethered intermediate by adopting intermolecular 1,3-dipolar cycloaddition of nitrile oxide in the presence of the environmentally safe sodium hypochloride oxidant under mild reaction conditions. The structures of all the synthesized compounds were confirmed by <sup>1</sup>H and <sup>13</sup>C NMR, ESI–MS, and ESI-HRMS.</p>

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Synthesis of a New Class of Functionalized Isoxazole/Isoxazoline Styrylchromone Derivatives

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • P. Limbadri,
  • Y. Hemasri

摘要

Abstract

A simple and practical method of synthesis of a new series of functionalized isoxazole/isoxazoline styrylchromone derivatives from 3-hydroxy-2-styrylchromone via an alkene/alkyne-tethered intermediate by adopting intermolecular 1,3-dipolar cycloaddition of nitrile oxide in the presence of the environmentally safe sodium hypochloride oxidant under mild reaction conditions. The structures of all the synthesized compounds were confirmed by 1H and 13C NMR, ESI–MS, and ESI-HRMS.