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Abstract <p>The results of studying the synthesis and antiproliferative activity of new 4-(1<i>H</i>-benzimidazol-2-yl)­benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target com­pounds were obtained by the acylation of <i>N</i>-(pyrimidin-2-yl)-<i>m</i>-phenylenediamines with 4-(1<i>H</i>-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1<i>H</i>-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.</p>

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Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • E. V. Koroleva,
  • A. L. Ermolinskaya,
  • Zh. V. Ignatovich,
  • O. V. Panibrat,
  • Thi-Kim-Dung Hoang,
  • Thi-Kim-Chi Huynh,
  • Thi-Cam-Thu Nguyen

摘要

Abstract

The results of studying the synthesis and antiproliferative activity of new 4-(1H-benzimidazol-2-yl)­benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target com­pounds were obtained by the acylation of N-(pyrimidin-2-yl)-m-phenylenediamines with 4-(1H-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1H-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.