Scholarlink

Abstract <p>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, including dementia, dysphasia, and visual impairments. In this study, substituted hydroxycoumarins <b>1</b> were synthesized from ethyl acetoacetate and resorcinol derivatives. The allylation of compounds <b>1</b> with allyl bromide involved the hydroxy group to give allyloxycoumarins <b>2</b> which underwent regioselective Claisen rearrangement to afford 8-allyl-7-hydroxycoumarins rather than 6-allyl-7-hydroxy-substituted analogues. The subsequent cyclization under various reaction conditions predominantly produced angular furocoumarins (angelicins) over linear isomers (psoralens). A molecular docking study was conducted to evaluate the potential of the synthesized derivatives as anti-Alzheimer agents, and selected compounds were assessed for their drug-likeness properties. The results demonstrated promising activity in comparison to reference drugs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regioselective Synthesis of Furocoumarin Derivatives and Their Docking and ADME Studies for Alzheimer’s Disease

  • 期刊论文

  • 发表日期：

    2025年4月1日

查看全文
  • M. N. Lokhande,
  • M. P. Kawale,
  • M. M. Kodape

摘要

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, including dementia, dysphasia, and visual impairments. In this study, substituted hydroxycoumarins 1 were synthesized from ethyl acetoacetate and resorcinol derivatives. The allylation of compounds 1 with allyl bromide involved the hydroxy group to give allyloxycoumarins 2 which underwent regioselective Claisen rearrangement to afford 8-allyl-7-hydroxycoumarins rather than 6-allyl-7-hydroxy-substituted analogues. The subsequent cyclization under various reaction conditions predominantly produced angular furocoumarins (angelicins) over linear isomers (psoralens). A molecular docking study was conducted to evaluate the potential of the synthesized derivatives as anti-Alzheimer agents, and selected compounds were assessed for their drug-likeness properties. The results demonstrated promising activity in comparison to reference drugs.